Transcription Factor Classification

SuperclassClassFamilySubfamily
1: Basic Domains1.1: Leucine zipper factors (bZIP)1.1.1: AP-1(-like) components1.1.1.1: Jun
1.1.1.2: Fos
1.1.1.3: Maf
1.1.1.4: NF-E2
1.1.1.5: fungal AP-1-like factors
1.1.1.6: CRE-BP/ATF
1.1.1.0: Others
1.1.2: CREB1.1.2.0: CREB
1.1.3: C/EBP-like factors1.1.3.0: C/EBP-like factors
1.1.4: bZIP / PAR1.1.4.0: bZIP / PAR
1.1.5: Plant G-box binding factors1.1.5.1: CPRF-2 ("V")
1.1.5.2: EmBP-1 ("E")
1.1.5.3: HBP-1a ("Q")
1.1.5.4: TGA1a ("L/M")
1.1.5.5: TGA1b ("R")
1.1.6: ZIP only1.1.6.0: ZIP only
1.1.0: Other bZIP factors1.1.0.0: Other bZIP factors
1.2: Helix-loop-helix factors (bHLH)1.2.1: Ubiquitous (class A) factors1.2.1.0: Ubiquitous (class A) factors
1.2.2: Myogenic transcription factors1.2.2.0: Myogenic transcription factors
1.2.3: Achaete-Scute1.2.3.0: Achaete-Scute
1.2.4: Tal/Twist/Atonal/Hen1.2.4.1: Lymphoid factors
1.2.4.2: Mesodermal Twist-like factors
1.2.4.3: HEN
1.2.4.4: Atonal
1.2.4.5: Pancreatic factors
1.2.5: Hairy1.2.5.1: Hairy
1.2.5.2: Esp
1.2.5.3: Fungal regulators
1.2.6: Factors with PAS domain1.2.6.0: Factors with PAS domain
1.2.7: INO1.2.7.0: INO
1.2.8: HLH domain only1.2.8.0: HLH domain only
1.2.0: Other bHLH factors1.2.0.0: Other bHLH factors
1.3: Helix-loop-helix / leucine zipper factors (bHLH-ZIP)1.3.1: Ubiquitous bHLH-ZIP factors1.3.1.1: TFE3
1.3.1.2: USF
1.3.1.3: SREBP
1.3.1.4: AP-4
1.3.2: Cell-cycle controlling factors1.3.2.1: Myc
1.3.2.2: Mad/Max
1.6: bHSH1.6.1: AP-21.6.1.0: AP-2
2: Zinc-coordinating DNA-binding domains2.1: Cys4 zinc finger of nuclear receptor type2.1.1: Steroid hormone receptors (NR3)2.1.1.1: Corticoid receptors (NR3C)
2.1.1.2: Progesterone receptor (NR3C)
2.1.1.3: Androgen receptor (NR3C)
2.1.1.4: Estrogen receptor (NR3A)
2.1.1.5: Estrogen related receptor (NR3B)
2.1.2: Thyroid hormone receptor-like factors (NR0, NR1, NR2, NR4, NR5, NR6)2.1.2.1: Thyroid hormone receptors (NR1A)
2.1.2.2: Retinoic acid receptors (NR1B)
2.1.2.3: PPAR (NR1C)
2.1.2.4: Rev-Erb receptors (NR1D)
2.1.2.5: NR1E
2.1.2.6: ROR (NR1F)
2.1.2.8: EcR/LXR/FXR (NR1H)
2.1.2.9: VDR/PXR/CAR (NR1I)
2.1.2.10: NR1J
2.1.2.11: HNF-4 (NR2A)
2.1.2.12: Retinoid X receptors (NR2B)
2.1.2.13: NR2C
2.1.2.14: NR2D
2.1.2.15: NR2E
2.1.2.16: COUP (NR2F)
2.1.2.17: Neuron-derived orphan receptors (NR4A)
2.1.2.18: FTZ-F1 related factors (NR5A)
2.1.2.19: NR5B
2.1.2.20: germ cell derived nuclear receptors (NR6A)
2.1.2.21: Knirps (NR0A)
2.1.2.22: NR0B
2.2: diverse Cys4 zinc fingers2.2.1: GATA-Factors2.2.1.1: vertebral GATA-Factors
2.2.1.2: fungal metabolic regulators
2.2.2: Trithorax2.2.2.0: Trithorax
2.2.0: Other factors2.2.0.0: Other factors
2.3: Cys2His2 zinc finger domain2.3.1: Ubiquitous factors2.3.1.0: Ubiquitous factors
2.3.2: Developmental / cell cycle regulators2.3.2.1: Egr/Krox
2.3.2.2: Krueppel-like
2.3.2.3: GLI-like
2.3.2.4: Gfi-like
2.3.2.0: Others
2.3.3: Metabolic regulators in fungi2.3.3.0: Metabolic regulators in fungi
2.3.4: Large factors with NF-6B-like binding properties2.3.4.0: Large factors with NF-6B-like binding properties
2.3.5: Viral regulators2.3.5.0: Viral regulators
2.4: Cys6 cysteine-zinc cluster2.4.1: Metabolic regulators in fungi2.4.1.0: Metabolic regulators in fungi
2.5: Zinc fingers of alternating composition2.5.1: Cx7Hx8Cx4C zinc fingers2.5.1.0: Cx7Hx8Cx4C zinc fingers
2.5.2: Cx2Hx4Hx4C zinc fingers2.5.2.0: Cx2Hx4Hx4C zinc fingers
3: Helix-turn-helix3.1: Homeo domain3.1.1: Homeo domain only3.1.1.1: AbdB
3.1.1.2: Antp
3.1.1.3: Cad
3.1.1.4: Cut
3.1.1.5: Dll
3.1.1.6: Ems
3.1.1.7: En
3.1.1.8: Eve
3.1.1.9: Prd
3.1.1.10: HD-ZIP
3.1.1.11: H2.0
3.1.1.12: HNF1
3.1.1.13: Lab
3.1.1.14: Msh
3.1.1.15: NK-2/Nkx
3.1.1.16: Bcd
3.1.1.17: XANF
3.1.1.18: PBC
3.1.1.0: not assigned
3.1.2: POU domain factors3.1.2.1: I
3.1.2.2: II
3.1.2.3: III
3.1.2.4: IV
3.1.2.5: V
3.1.2.6: VI
3.1.2.0: other POU factors
3.1.3: Homeo domain with LIM region3.1.3.1: Homeo domain with LIM region
3.1.3.2: LIM-only transcription (co-)factors
3.1.4: homeo domain plus zinc finger motifs3.1.4.0: homeo domain plus zinc finger motifs
3.2: Paired box3.2.1: Paired plus homeo domain3.2.1.0: Paired plus homeo domain
3.2.2: Paired domain only3.2.2.1: Pax-1 and homologs
3.2.2.2: Pax-2 and homologs
3.2.2.3: Pax-5
3.2.2.4: Pax-8
3.2.2.5: Pax-9
3.3: Fork head / winged helix3.3.1: Developmental regulators3.3.1.0: Developmental regulators
3.3.2: Tissue-specific regulators3.3.2.0: Tissue-specific regulators
3.3.3: Cell-cycle controlling factors3.3.3.1: vertebrate E2F
3.3.3.2: DP
3.3.3.3: insect E2F
3.3.3.4: fungal E2F
3.3.3.5: plant E2F
3.3.4: Regulators with a DNA recognition wing3.3.4.1: RFX
3.3.0: Other regulators3.3.0.0: Other regulators
3.4: Heat shock factors3.4.1: HSF3.4.1.0: HSF
3.5: Tryptophan clusters3.5.1: Myb3.5.1.1: Myb-factors
3.5.1.2: Myb-like factors
3.5.2: Ets-type3.5.2.0: Ets-type
3.5.3: Interferon-regulating factors3.5.3.0: Interferon-regulating factors
3.6: TEA domain3.6.1: TEA3.6.1.0: TEA
3.6.1.1: vertebrate TEA/ATTS, muscle-spesific
4: beta-Scaffold Factors with Minor Groove Contacts4.1: RHR (Rel homology region)4.1.1: Rel/ankyrin4.1.1.0: Rel/ankyrin
4.1.2: ankyrin only4.1.2.0: ankyrin only
4.1.3: NF-AT4.1.3.0: NF-AT
4.2: STAT4.2.1: STAT4.2.1.0: STAT
4.3: p534.3.1: p53-like4.3.1.1: p53
4.3.1.2: p63
4.3.1.3: p73
4.4: MADS box4.4.1: Regulators of differentiation4.4.1.1: MEF-2
4.4.1.2: homeotic genes
4.4.1.3: yeast regulators
4.4.2: Responders to external signals4.4.2.0: Responders to external signals
4.4.3: Metabolic regulators4.4.3.0: Metabolic regulators
4.5: beta-Barrel alpha-helix transcription factors4.5.1: E24.5.1.0: E2
4.6: TATA-binding proteins4.6.1: TBP4.6.1.0: TBP
4.7: HMG4.7.1: SOX4.7.1.0: SOX
4.7.2: TCF-14.7.2.0: TCF-1
4.7.3: HMG2-related4.7.3.0: HMG2-related
4.7.4: UBF4.7.4.0: UBF
4.7.5: MATA4.7.5.0: MATA
4.7.0: Other HMG box factors4.7.0.0: Other HMG box factors
4.8: Histone fold4.8.1: Heteromeric CCAAT factors4.8.1.0: Heteromeric CCAAT factors
4.8.2: General transcription factors with histone fold4.8.2.0: General transcription factors with histone fold
4.9: Grainyhead4.9.1: LSF/CP24.9.1.0: LSF/CP2
4.9.2: Grainyhead4.9.2.0: Grainyhead
4.10: Cold-shock domain factors4.10.1: csd4.10.1.1: A (DbpA-like)
4.10.1.2: B (YB-1/DbpB-like)
4.10.1.3: C (FRG Y2-like)
4.11: Runt4.11.1: Runt4.11.1.1: PEBP2alphaA
4.11.1.2: PEBP2alphaB
4.11.1.3: PEBP2alphaC
4.11.1.4: Runt
4.11.1.5: Lozenge
4.12: SMAD/NF-14.12.1: SMAD4.12.1.1: receptor-regulated SMADs
4.12.1.2: common mediator SMADs
4.12.1.3: inhibitory SMADs
4.12.2: NF-14.12.2.0: NF-1
0: Other Transcription Factors0.1: Copper fist proteins0.1.1: Fungal regulators0.1.1.0: Fungal regulators
0.2: HMGI(Y)0.2.1: HMGI(Y)0.2.1.0: HMGI(Y)
0.3: Pocket domain0.3.1: Rb0.3.1.0: Rb
0.3.2: CBP0.3.2.0: CBP
0.4: E1A-like factors0.4.1: E1A0.4.1.0: E1A
0.5: AP2/EREBP-related factors0.5.1: AP20.5.1.0: AP2
0.5.2: EREBP0.5.2.0: EREBP
0.5.3: AP2/B30.5.3.0: AP2/B3