Superclass | Class | Family | Subfamily |
1: Basic Domains | 1.1: Leucine zipper factors (bZIP) | 1.1.1: AP-1(-like) components | 1.1.1.1: Jun |
1.1.1.2: Fos |
1.1.1.3: Maf |
1.1.1.4: NF-E2 |
1.1.1.5: fungal AP-1-like factors |
1.1.1.6: CRE-BP/ATF |
1.1.1.0: Others |
1.1.2: CREB | 1.1.2.0: CREB |
1.1.3: C/EBP-like factors | 1.1.3.0: C/EBP-like factors |
1.1.4: bZIP / PAR | 1.1.4.0: bZIP / PAR |
1.1.5: Plant G-box binding factors | 1.1.5.1: CPRF-2 ("V") |
1.1.5.2: EmBP-1 ("E") |
1.1.5.3: HBP-1a ("Q") |
1.1.5.4: TGA1a ("L/M") |
1.1.5.5: TGA1b ("R") |
1.1.6: ZIP only | 1.1.6.0: ZIP only |
1.1.0: Other bZIP factors | 1.1.0.0: Other bZIP factors |
1.2: Helix-loop-helix factors (bHLH) | 1.2.1: Ubiquitous (class A) factors | 1.2.1.0: Ubiquitous (class A) factors |
1.2.2: Myogenic transcription factors | 1.2.2.0: Myogenic transcription factors |
1.2.3: Achaete-Scute | 1.2.3.0: Achaete-Scute |
1.2.4: Tal/Twist/Atonal/Hen | 1.2.4.1: Lymphoid factors |
1.2.4.2: Mesodermal Twist-like factors |
1.2.4.3: HEN |
1.2.4.4: Atonal |
1.2.4.5: Pancreatic factors |
1.2.5: Hairy | 1.2.5.1: Hairy |
1.2.5.2: Esp |
1.2.5.3: Fungal regulators |
1.2.6: Factors with PAS domain | 1.2.6.0: Factors with PAS domain |
1.2.7: INO | 1.2.7.0: INO |
1.2.8: HLH domain only | 1.2.8.0: HLH domain only |
1.2.0: Other bHLH factors | 1.2.0.0: Other bHLH factors |
1.3: Helix-loop-helix / leucine zipper factors (bHLH-ZIP) | 1.3.1: Ubiquitous bHLH-ZIP factors | 1.3.1.1: TFE3 |
1.3.1.2: USF |
1.3.1.3: SREBP |
1.3.1.4: AP-4 |
1.3.2: Cell-cycle controlling factors | 1.3.2.1: Myc |
1.3.2.2: Mad/Max |
1.6: bHSH | 1.6.1: AP-2 | 1.6.1.0: AP-2 |
2: Zinc-coordinating DNA-binding domains | 2.1: Cys4 zinc finger of nuclear receptor type | 2.1.1: Steroid hormone receptors (NR3) | 2.1.1.1: Corticoid receptors (NR3C) |
2.1.1.2: Progesterone receptor (NR3C) |
2.1.1.3: Androgen receptor (NR3C) |
2.1.1.4: Estrogen receptor (NR3A) |
2.1.1.5: Estrogen related receptor (NR3B) |
2.1.2: Thyroid hormone receptor-like factors (NR0, NR1, NR2, NR4, NR5, NR6) | 2.1.2.1: Thyroid hormone receptors (NR1A) |
2.1.2.2: Retinoic acid receptors (NR1B) |
2.1.2.3: PPAR (NR1C) |
2.1.2.4: Rev-Erb receptors (NR1D) |
2.1.2.5: NR1E |
2.1.2.6: ROR (NR1F) |
2.1.2.8: EcR/LXR/FXR (NR1H) |
2.1.2.9: VDR/PXR/CAR (NR1I) |
2.1.2.10: NR1J |
2.1.2.11: HNF-4 (NR2A) |
2.1.2.12: Retinoid X receptors (NR2B) |
2.1.2.13: NR2C |
2.1.2.14: NR2D |
2.1.2.15: NR2E |
2.1.2.16: COUP (NR2F) |
2.1.2.17: Neuron-derived orphan receptors (NR4A) |
2.1.2.18: FTZ-F1 related factors (NR5A) |
2.1.2.19: NR5B |
2.1.2.20: germ cell derived nuclear receptors (NR6A) |
2.1.2.21: Knirps (NR0A) |
2.1.2.22: NR0B |
2.2: diverse Cys4 zinc fingers | 2.2.1: GATA-Factors | 2.2.1.1: vertebral GATA-Factors |
2.2.1.2: fungal metabolic regulators |
2.2.2: Trithorax | 2.2.2.0: Trithorax |
2.2.0: Other factors | 2.2.0.0: Other factors |
2.3: Cys2His2 zinc finger domain | 2.3.1: Ubiquitous factors | 2.3.1.0: Ubiquitous factors |
2.3.2: Developmental / cell cycle regulators | 2.3.2.1: Egr/Krox |
2.3.2.2: Krueppel-like |
2.3.2.3: GLI-like |
2.3.2.4: Gfi-like |
2.3.2.0: Others |
2.3.3: Metabolic regulators in fungi | 2.3.3.0: Metabolic regulators in fungi |
2.3.4: Large factors with NF-6B-like binding properties | 2.3.4.0: Large factors with NF-6B-like binding properties |
2.3.5: Viral regulators | 2.3.5.0: Viral regulators |
2.4: Cys6 cysteine-zinc cluster | 2.4.1: Metabolic regulators in fungi | 2.4.1.0: Metabolic regulators in fungi |
2.5: Zinc fingers of alternating composition | 2.5.1: Cx7Hx8Cx4C zinc fingers | 2.5.1.0: Cx7Hx8Cx4C zinc fingers |
2.5.2: Cx2Hx4Hx4C zinc fingers | 2.5.2.0: Cx2Hx4Hx4C zinc fingers |
3: Helix-turn-helix | 3.1: Homeo domain | 3.1.1: Homeo domain only | 3.1.1.1: AbdB |
3.1.1.2: Antp |
3.1.1.3: Cad |
3.1.1.4: Cut |
3.1.1.5: Dll |
3.1.1.6: Ems |
3.1.1.7: En |
3.1.1.8: Eve |
3.1.1.9: Prd |
3.1.1.10: HD-ZIP |
3.1.1.11: H2.0 |
3.1.1.12: HNF1 |
3.1.1.13: Lab |
3.1.1.14: Msh |
3.1.1.15: NK-2/Nkx |
3.1.1.16: Bcd |
3.1.1.17: XANF |
3.1.1.18: PBC |
3.1.1.0: not assigned |
3.1.2: POU domain factors | 3.1.2.1: I |
3.1.2.2: II |
3.1.2.3: III |
3.1.2.4: IV |
3.1.2.5: V |
3.1.2.6: VI |
3.1.2.0: other POU factors |
3.1.3: Homeo domain with LIM region | 3.1.3.1: Homeo domain with LIM region |
3.1.3.2: LIM-only transcription (co-)factors |
3.1.4: homeo domain plus zinc finger motifs | 3.1.4.0: homeo domain plus zinc finger motifs |
3.2: Paired box | 3.2.1: Paired plus homeo domain | 3.2.1.0: Paired plus homeo domain |
3.2.2: Paired domain only | 3.2.2.1: Pax-1 and homologs |
3.2.2.2: Pax-2 and homologs |
3.2.2.3: Pax-5 |
3.2.2.4: Pax-8 |
3.2.2.5: Pax-9 |
3.3: Fork head / winged helix | 3.3.1: Developmental regulators | 3.3.1.0: Developmental regulators |
3.3.2: Tissue-specific regulators | 3.3.2.0: Tissue-specific regulators |
3.3.3: Cell-cycle controlling factors | 3.3.3.1: vertebrate E2F |
3.3.3.2: DP |
3.3.3.3: insect E2F |
3.3.3.4: fungal E2F |
3.3.3.5: plant E2F |
3.3.4: Regulators with a DNA recognition wing | 3.3.4.1: RFX |
3.3.0: Other regulators | 3.3.0.0: Other regulators |
3.4: Heat shock factors | 3.4.1: HSF | 3.4.1.0: HSF |
3.5: Tryptophan clusters | 3.5.1: Myb | 3.5.1.1: Myb-factors |
3.5.1.2: Myb-like factors |
3.5.2: Ets-type | 3.5.2.0: Ets-type |
3.5.3: Interferon-regulating factors | 3.5.3.0: Interferon-regulating factors |
3.6: TEA domain | 3.6.1: TEA | 3.6.1.0: TEA |
3.6.1.1: vertebrate TEA/ATTS, muscle-spesific |
4: beta-Scaffold Factors with Minor Groove Contacts | 4.1: RHR (Rel homology region) | 4.1.1: Rel/ankyrin | 4.1.1.0: Rel/ankyrin |
4.1.2: ankyrin only | 4.1.2.0: ankyrin only |
4.1.3: NF-AT | 4.1.3.0: NF-AT |
4.2: STAT | 4.2.1: STAT | 4.2.1.0: STAT |
4.3: p53 | 4.3.1: p53-like | 4.3.1.1: p53 |
4.3.1.2: p63 |
4.3.1.3: p73 |
4.4: MADS box | 4.4.1: Regulators of differentiation | 4.4.1.1: MEF-2 |
4.4.1.2: homeotic genes |
4.4.1.3: yeast regulators |
4.4.2: Responders to external signals | 4.4.2.0: Responders to external signals |
4.4.3: Metabolic regulators | 4.4.3.0: Metabolic regulators |
4.5: beta-Barrel alpha-helix transcription factors | 4.5.1: E2 | 4.5.1.0: E2 |
4.6: TATA-binding proteins | 4.6.1: TBP | 4.6.1.0: TBP |
4.7: HMG | 4.7.1: SOX | 4.7.1.0: SOX |
4.7.2: TCF-1 | 4.7.2.0: TCF-1 |
4.7.3: HMG2-related | 4.7.3.0: HMG2-related |
4.7.4: UBF | 4.7.4.0: UBF |
4.7.5: MATA | 4.7.5.0: MATA |
4.7.0: Other HMG box factors | 4.7.0.0: Other HMG box factors |
4.8: Histone fold | 4.8.1: Heteromeric CCAAT factors | 4.8.1.0: Heteromeric CCAAT factors |
4.8.2: General transcription factors with histone fold | 4.8.2.0: General transcription factors with histone fold |
4.9: Grainyhead | 4.9.1: LSF/CP2 | 4.9.1.0: LSF/CP2 |
4.9.2: Grainyhead | 4.9.2.0: Grainyhead |
4.10: Cold-shock domain factors | 4.10.1: csd | 4.10.1.1: A (DbpA-like) |
4.10.1.2: B (YB-1/DbpB-like) |
4.10.1.3: C (FRG Y2-like) |
4.11: Runt | 4.11.1: Runt | 4.11.1.1: PEBP2alphaA |
4.11.1.2: PEBP2alphaB |
4.11.1.3: PEBP2alphaC |
4.11.1.4: Runt |
4.11.1.5: Lozenge |
4.12: SMAD/NF-1 | 4.12.1: SMAD | 4.12.1.1: receptor-regulated SMADs |
4.12.1.2: common mediator SMADs |
4.12.1.3: inhibitory SMADs |
4.12.2: NF-1 | 4.12.2.0: NF-1 |
0: Other Transcription Factors | 0.1: Copper fist proteins | 0.1.1: Fungal regulators | 0.1.1.0: Fungal regulators |
0.2: HMGI(Y) | 0.2.1: HMGI(Y) | 0.2.1.0: HMGI(Y) |
0.3: Pocket domain | 0.3.1: Rb | 0.3.1.0: Rb |
0.3.2: CBP | 0.3.2.0: CBP |
0.4: E1A-like factors | 0.4.1: E1A | 0.4.1.0: E1A |
0.5: AP2/EREBP-related factors | 0.5.1: AP2 | 0.5.1.0: AP2 |
0.5.2: EREBP | 0.5.2.0: EREBP |
0.5.3: AP2/B3 | 0.5.3.0: AP2/B3 |